Arnout R. D. Voet

DESPOT improves protein-ligand docking by introducing anisotropic scoring potentials that outperform isotropic methods in docking accuracy and virtual screening.

An automated pipeline turns the PDB into 178,263 repaired, protonated, restraint-minimized protein-ligand complexes; scoring functions trained on them beat HiQBind-trained ones on CASF-2016 ranking and docking power.

The paper introduces SAKe, a designer protein that forms stable, pH-dependent two-dimensional assemblies for functional protein-based materials.

This paper identifies EPB-113, a guanidine-based inhibitor of coronavirus nsp15 endoribonuclease, which suppresses viral replication and selects for interferon-susceptible mutants.

This study characterizes the ACO gene family in Arabidopsis, showing tissue-specific ethylene production and its role in stress responses, but not essential for normal development.

The paper introduces a cost-effective and scalable method for isolating RNA-protein complexes, validated in yeast and demonstrated in plants.

The paper designs and crystallizes two symmetric nine-bladed propeller proteins, which adopt pseudo-symmetric eight-fold conformations with distorted termini.