Xiang Zhao

This study measures single-cell transcriptional dynamics in zebrafish embryos using MS2-MCP labeling and light sheet microscopy, revealing discrete transcriptional bursts in the segmentation clock.

This study shows that Pcm1 regulates asymmetric endosome dynamics and RGP fate by coordinating Rab5b and Rab11a endosome markers and Par-3/dynein complexes in zebrafish and human brain organoids.

Ultrack improves cell tracking across 2D, 3D, and multi-channel time-lapse recordings by integrating multiple segmentations and temporal consistency, achieving state-of-the-art performance on benchmark datasets.

The paper presents Zebrahub-Multiome, a single-cell multiomic atlas of zebrafish embryogenesis, revealing gene regulatory network dynamics and cis-regulatory elements across developmental stages.

Zebrafish embryos sequenced individually across ten developmental stages, paired with light-sheet lineage reconstruction, form an atlas and browser for in silico fate mapping.

This paper introduces a novel single objective light-sheet microscope that achieves high resolution, large field of view, and multi-view imaging for various biological systems.