Merlin Lange

This study measures single-cell transcriptional dynamics in zebrafish embryos using MS2-MCP labeling and light sheet microscopy, revealing discrete transcriptional bursts in the segmentation clock.

This study compares five RNA velocity methods across three datasets to evaluate their performance in predicting cellular states.

inTRACKtive provides a web-based tool for interactive visualization and sharing of large 3D cell tracking datasets without requiring software installation or data downloads.

Ultrack improves cell tracking across 2D, 3D, and multi-channel time-lapse recordings by integrating multiple segmentations and temporal consistency, achieving state-of-the-art performance on benchmark datasets.

The paper presents Zebrahub-Multiome, a single-cell multiomic atlas of zebrafish embryogenesis, revealing gene regulatory network dynamics and cis-regulatory elements across developmental stages.

This paper describes OME-Zarr, a cloud-optimized bioimaging file format developed through community collaboration to improve scalability and data access.

Zebrafish embryos sequenced individually across ten developmental stages, paired with light-sheet lineage reconstruction, form an atlas and browser for in silico fate mapping.

This paper introduces a novel single objective light-sheet microscope that achieves high resolution, large field of view, and multi-view imaging for various biological systems.

The paper introduces ZAF, an open-source automated feeding system for aquatic facilities, which provides standardized food distribution and is adaptable to various laboratory environments.

This paper introduces a deep learning framework for correcting optical aberrations in microscopy by estimating wavefront phases and performing blind deconvolution.

The paper shows that Retinoic Acid signaling, specifically through Rere, controls brain asymmetry and handedness in zebrafish and mouse.