Author

Shayla R. Mosley

University of AlbertaORCID 0000-0002-3372-4350Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Kristi BakeriD· 3 shared Angie Chen· 2 shared Courtney MowatiD· 2 shared Felix Meier‐Stephenson· 2 shared Vanessa Meier‐StephensoniD· 2 shared Afshin NamdariD· 1 shared Alain Morejon Morales· 1 shared Alexandra K. KiemeriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

Kristi BakerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cytosolic DNA structures produced by mismatch-repair deficiency coordinate anti-tumor immunity in colorectal cancer

Shayla R. Mosley, Natalie Lapa, Afshin Namdar, Thomas E. Catley, Felix Meier‐Stephenson, Courtney Mowat, Pinzhang Gao, Xuejun Sun, Vanessa Meier‐Stephenson, Alice L. B. Pyne, Kristi Baker

The paper identifies cytosolic DNA structures in MSI CRC that enhance STING activation and anti-tumor immunity, suggesting potential for improved DNA-based therapies.

Cell Reports · Feb 19, 2026Peer-reviewedCancer Biology

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

Chelsea E. Cunningham, Frederick S. Vizeacoumar, Yue Zhang, Liliia Kyrylenko, Simon Both, Vincent Maranda, He Dong, Jared D. W. Price, Peng Gao, Konrad Wagner, Yingwen Wu, Mary Lazell-Wright, Ashtalakshmi Ganapathysamy, Rithik Hari, Kalpana Kalyanasundaram Bhanumathy, , Franco J. Vizeacoumar

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

Cell Genomics · May 9, 2025Peer-reviewedCancer Biology

Mechanisms of genomic instability dictate cytosolic DNA composition and dendritic cell mediated anti-tumor immunity

Shayla R. Mosley, Angie Chen, David N.W. Doell, Siwon Choi, Courtney Mowat, Felix Meier‐Stephenson, Vanessa Meier‐Stephenson, Kristi Baker

The paper shows that genomic instability in MSI CRCs generates cytosolic DNA that enhances STING activation and anti-tumor immunity via dendritic cells, suggesting improved DNA-based therapies for CIN CRCs.

Cell Reports · Jan 24, 2025Peer-reviewedCancer Biology