Manjula Kalia

The mitochondrial transaminase GOT2 supports Japanese encephalitis virus replication in neuronal cells

This study identifies the mitochondrial transaminase GOT2 as a metabolic dependency of JEV and a potential host-directed antiviral target through integrated transcriptomics and proteomics analyses.

Trifluoperazine exhibits broad-spectrum antiviral activity against arboviruses

This study identifies Trifluoperazine as a broad-spectrum antiviral effective against JEV, DENV, and CHIKV in vitro and in vivo.

STING is a key driver of Japanese encephalitis virus induced inflammatory response

This study shows STING restricts JEV replication and drives inflammatory responses through NLRP3 inflammasome activation and pyroptosis.

AGPAT1 is a novel Chikungunya virus receptor on human cells

This study identifies AGPAT1 as a novel receptor for Chikungunya virus on human cells, showing its role in virus binding, uptake, and replication.

Endophilin mediated endocytosis and Epidermal growth factor receptor govern Japanese encephalitis virus entry and infection in neuronal cells

This study identifies Endophilin and EGFR as essential host factors for Japanese encephalitis virus entry and infection in neuronal cells through clathrin-independent endocytosis.