Jonas Zähringer

FACT frees Ubp10 from nucleosome sequestration after rapid H2B deubiquitination

The paper shows that FACT facilitates Ubp10 release from nucleosomes after H2B deubiquitination, revealing release as the rate-limiting step for Ubp10 turnover.

Direct visualization of MCM helicase activation and replisome coupling in situ

This study uses MINFLUX nanoscopy to directly visualize MCM helicase activation and replisome coupling in human cells, showing sister replisomes remain coupled at ~40 nm during S phase.

A Modular Framework for Automated Segmentation and Analysis of AFM Imaging of Chromatin Organization

DNAsight automates AFM image analysis of chromatin organization, revealing protein-specific structural signatures and nucleosome spacing distributions.

Brownian DNA Computing

This paper introduces Brownian DNA computing, a molecular computing framework that uses DNA origami scaffolds to implement logic gates and circuits through thermal fluctuations, enabling energy-efficient and reversible computation.