Sarah Huet

Relapse-founding cancer persister cells in follicular lymphoma

This study identifies relapse-founding cancer persister cells in follicular lymphoma using a mouse model and shows their transcriptional program is conserved in humans, with potential therapeutic targets identified.

Detecting aberrant splicing events in short-read RNA-seq with SAMI, an UMI-aware Nextflow pipeline

SAMI detects aberrant splicing events in short-read RNA-seq by focusing on non-recurring events in low-dimension data using a UMI-aware pipeline.

Performances of targeted RNA-sequencing for the analysis of fusion transcripts, gene mutation and expression in haematological malignancies.

This study evaluates targeted RNA sequencing for detecting fusion transcripts, mutations, and expression in hematological malignancies, finding it effective for diagnosing leukemia subtypes and identifying most DNA mutations at the mRNA level.