Author
Harvard UniversityORCID 0000-0002-3945-6529Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
Recent·Most cited
Yi Chai, Ruiying Zhang, Shunze Jia, Danfei Zhu, Si-Yi Chen, Shuai Liu, Na Kong, Xudong Fu, Xin Sheng
Toti is a multi-omics database that provides epigenetic and transcriptomic resources for studying totipotent stem cells, offering tools for exploration and analysis.
Stem Cell Reports · Aug 21, 2025Peer-reviewedDevelopmental Biology
Mengying Zhou, Rui Fang, Louis Colson, Katherine A. Donovan, Moritz Hunkeler, Yuyu Song, Can Martin Zhang, Si-Yi Chen, Dong Hoon Lee, Gary Andrew Bradshaw, Robyn J. Eisert, Yihong Ye, Marian Kalocsay, Alfred Lewis Goldberg, Eric S. Fischer, Ying Lu
This paper identifies HUWE1 as a ubiquitin ligase that enhances ubiquitin modifications on proteins and aggregates, promoting their degradation via proteasome and autophagy pathways.
bioRxiv · May 30, 2023 · PreprintMolecular Biology
Dong Hoon Lee, Yanan Zhu, Louis Colson, Xiaorong Wang, Si-Yi Chen, Emre Tkacik, Lan Huang, Qi Ouyang, Alfred Lewis Goldberg, Ying Lu
The paper investigates how ZFAND5 activates the 26S proteasome by inducing conformational changes that enhance substrate degradation.
bioRxiv · May 9, 2023 · PreprintMolecular Biology