Nirmatrelvir-Resistant Mutations in SARS-CoV-2 Mpro Enhance Host Immune Evasion via Cleavage of NF-κB Essential Modulator
Merrilee A. Thomas, Thomas E. Hughes
The paper shows that Nirmatrelvir-resistant mutations in SARS-CoV-2 Mpro enhance immune evasion by cleaving NEMO, leading to reduced immune response and improved viral replication.