Gating of hair cell Ca2+ channels governs the activity of cochlear neurons
Nare Karagulyan, Anupriya Thirumalai, Susann Michanski, Yumeng Qi, Qinghua Fang, Haoyu Wang, Nadine J. Ortner, Jörg Striessnig, Nicola Strenzke, Carolin Wichmann, Yunfeng Hua, Tobias Moser
This study shows that variations in Ca2+ channel activation in inner hair cells affect spiral ganglion neuron firing rates and sound threshold, with implications for noise-induced hearing loss in patients with the CaV1.3A749G mutation.
Science Advances · Jun 18, 2025Peer-reviewedNeuroscience