Susann Michanski

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system

This study shows that AP2 complex is essential for myelin sheath biogenesis and homeostasis, with loss of AP2 causing hypomyelination and hypermyelination in different developmental stages.

SynapseNet: Deep Learning for Automatic Synapse Reconstruction

SynapseNet automatically segments synapses in electron micrographs using deep learning, enabling efficient analysis of synaptic structures.

Gating of hair cell Ca2+ channels governs the activity of cochlear neurons

This study shows that variations in Ca2+ channel activation in inner hair cells affect spiral ganglion neuron firing rates and sound threshold, with implications for noise-induced hearing loss in patients with the CaV1.3A749G mutation.

Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

This study uses optogenetics and electron tomography to analyze the ultrastructure of cochlear inner hair cell ribbon synapses during stimulation, showing increased docked synaptic vesicles and no evidence of homotypic fusion.

Piccolino regulates the architecture of the ribbon at cochlear inner hair cell synapses

This study investigates the role of piccolino in cochlear inner hair cell synapses, finding it contributes to active zone organization and is essential for normal synaptic transmission.

Macromolecular and electrical coupling between inner hair cells in the rodent cochlea

The paper shows that 30% of inner hair cells in the rodent cochlea form electrochemical mini-syncytia through membrane fusion, enhancing sound encoding sensitivity and reliability.