Ying Zhao

The paper uses a SNAP25-based FRET construct to show SNARE complex assembly and disassembly dynamics in live cells, revealing that FRET ratio transients reflect complex disassembly rather than diffusion.

This study investigates how morphine affects the 3D chromatin architecture of primate cortical neurons using DLO Hi-C, finding significant changes in chromosome territories, TADs, and differential loops.

The paper identifies essential regulatory elements that maintain chromatin organization and cell viability through their role in 3D chromatin contacts, showing that non-essential genes can synergize to cause cell death.

The paper identifies non-coding genomic regions critical for chromatin organization and cell viability, showing their structural importance despite lacking epigenomic signals or annotated elements.

The paper identifies critical transcription factors and their regulatory networks during mouse embryonic development using epigenomic and transcriptomic data.

The paper expands DNA methylation data from TCGA using EAGLING, identifies triple-evidenced genes across 13 cancers, and reveals enriched pathways with potential therapeutic value.