Context-dependent requirement of H3K9 methyltransferase activity during cellular reprogramming to iPSCs
Simon E. Vidal, Alexander Polyzos, Jorge Morales-Valencia, Hongsu Wang, Emily Swanzey, Ly-Sha Ee, Bhishma Amlani, Shengjiang Tu, Yixiao Gong, Valentina Snetkova, Jane A. Skok, Aristotelis Tsirigos, Sang Yong Kim, Effie Apostolou, Matthias Stadtfeld
This study shows that reducing EHMT1/2 activity during reprogramming with ascorbic acid impairs iPSC formation and viability, highlighting the role of H3K9 methylation in reprogramming efficiency.
bioRxiv · Jun 18, 2019 · PreprintDevelopmental Biology