Yanan Han

This paper uses 6-base sequencing to analyze DNA modifications in cerebrospinal fluid cell-free DNA, providing insights into neurodegenerative biology for liquid biopsy applications.

The paper uses single-cell sequencing to show coordinated immune-cell changes between blood and CSF in early MS, with CSF enrichment of memory T-cells and B-cells and depletion of cytotoxic populations.

This study identifies DNA methylation changes in cerebrospinal fluid cells from MS patients, linking them to immune regulatory alterations and implicating protocadherins in MS pathogenesis.

The paper profiles small non-coding RNAs in multiple compartments of MS patients and controls, identifying distinct sncRNA expression patterns in CSF and PBMCs that suggest organ-specific regulatory mechanisms.