Author

Nils Hallen

Karolinska University Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Fredrik PiehliD· 3 shared Maria NeedhamseniD· 3 shared Chiara SoriniiD· 2 shared Ingrid Skelton KockumiD· 2 shared M Jagodic· 2 shared Majid Pahlevan KakhkiiD· 2 shared Mohsen KhademiiD· 2 shared Nicolas RuffiniD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Fredrik PiehlORCID

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3 papers

Recent·Most cited

Single-cell analysis suggests coordinated immune-cell redistribution between blood and cerebrospinal fluid in early multiple sclerosis

Nils Hallen, Sunjay Jude Fernandes, Soudabeh Rad Pour, Alexandra Gyllenberg, Yanan Han, Nicolas Ruffin, Narsis Kiani, Maria Needhamsen, Fredrik Piehl, Ingrid Skelton Kockum, Faiez Al Nimer, David Gómez-Cabrero, Jesper N. Tegner, Maja Jagodic

The paper uses single-cell sequencing to show coordinated immune-cell changes between blood and CSF in early MS, with CSF enrichment of memory T-cells and B-cells and depletion of cytotoxic populations.

bioRxiv · Aug 9, 2026 · PreprintImmunology

Epigenomic profiling of cerebrospinal fluid cells identifies immune regulatory alterations and implicates protocadherins in multiple sclerosis

Yanan Han, Galina Yurevna Zheleznyakova, Chiara Sorini, Majid Pahlevan Kakhki, Nicolas Ruffin, Heng Liang, Nils Hallen, Chandana Rao Prakash, Viveca Beckers, Elena Ivanova, Mohsen Khademi, Mikael C. I. Karlsson, Fredrik Piehl, Tomas P Olsson, Gavin Kelsey, , M Jagodic

This study identifies DNA methylation changes in cerebrospinal fluid cells from MS patients, linking them to immune regulatory alterations and implicating protocadherins in MS pathogenesis.

bioRxiv · Feb 27, 2026 · PreprintImmunology

Anoctamin-2-specific T Cells Link Epstein-Barr Virus to Multiple Sclerosis

Olivia G. Thomas, Urszula Rykaczewska, Marina Galesic, Rianne T. M. van der Burgt, Nils Hallen, Filippo Ferro, Mattias Bronge, Zoe Marti, Yue Li, Alexandra Hill Rique, Jianing Lin, Aleksa Krstic, Alicja Gromadzka, Andras Levente Szonder, Chiara Sorini, , Tomas P Olsson

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

Cell · Jan 1, 2026Peer-reviewedImmunology✦ In-depth digest