Ivo Díaz Ludovico

Carbamylome analysis reveals regulatory roles for lysine carbamylation in β-cell glycolytic and insulin-processing enzymes

The paper identifies carbamylation as a regulatory modification in β-cell metabolism and insulin processing in T1D by analyzing proteomic changes in NOD and MIN6 cells.

Assessing extracellular vesicle proteins as predictive biomarkers for developing type 1 diabetes

This study evaluates plasma extracellular vesicle proteomics for identifying predictive biomarkers of type 1 diabetes development, finding 448 differentially abundant proteins and a 0.81 AUC in predicting islet autoimmunity.

Unbiased proteomics following inflammasome activation identifies caspase targets in primary intestinal epithelial cells

This study uses mass spectrometry to identify caspase targets in primary intestinal epithelial cells following NAIP-NLRC4 inflammasome activation, revealing novel cleavage sites beyond known Caspase-1 substrates.

Sexually distinct multi omic responses to progressive endurance exercise training in the rat lung. Findings from MoTrPAC

This study identifies sex-specific multi-omic responses to endurance exercise training in rat lungs, revealing differences in immune pathways and mitochondrial acetylation between males and females.

Proinflammatory stress activates neutral sphingomyelinase 2 based generation of a ceramide-enriched β cell EV subpopulation

This study shows that proinflammatory stress in beta cells increases ceramide-enriched extracellular vesicles via nSMase2, which may affect paracrine signaling in diabetes.