David A. Gaul

Orbitrap Collision Cross Section Measurements Enhance Isomer Annotations in Lipidomics

This paper introduces a method to infer lipid CCS values from LC-Orbitrap MS data, improving isomer annotation in lipidomics with high precision and accuracy.

Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats

The paper identifies tissue-specific transcriptional regulatory programs in rats undergoing endurance exercise training by integrating chromatin accessibility, DNA methylation, and gene expression data.

PFOA induced metabolic and immune perturbations in a SARS-2 infection model

This study examines how PFOA exposure affects metabolism and immune response to SARS-2 in ferrets, finding altered metabolic responses and impaired immune function.

Sexually distinct multi omic responses to progressive endurance exercise training in the rat lung. Findings from MoTrPAC

This study identifies sex-specific multi-omic responses to endurance exercise training in rat lungs, revealing differences in immune pathways and mitochondrial acetylation between males and females.

Endurance exercise drives temporal and sexual dimorphic multi-omic adaptations in liver metabolism-Findings from MoTrPAC.

This study examines how endurance exercise affects liver metabolism in male and female rats over time, revealing sex-specific molecular changes and protective effects.

A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy

This paper identifies a novel HDAC inhibitor, STR-V-53, that effectively targets HCC and enhances immunotherapy responses in mouse models.

Spatial Lipidomics Maps Brain Alterations Associated with Mild Traumatic Brain Injury

This study uses spatial lipidomics to identify brain lipid alterations in rats with mild traumatic brain injury and repetitive mild traumatic brain injury.

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

The unknown lipids project: harmonized methods improve compound identification and data reproducibility in an inter-laboratory untargeted lipidomics study

The paper improves compound identification and inter-laboratory reproducibility in untargeted lipidomics using harmonized methods and spectral analysis.

The mitochondrial multi-omic response to exercise training across tissues

This study maps multi-omic mitochondrial changes across 19 tissues in rats after endurance exercise training, identifying tissue-specific adaptations and disease-related hubs.

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.