Tsvetelina H. Baryakova

Novel approaches to label the surface of S. aureus with DBCO for click chemistry-mediated deposition of sensitive cargo

This paper introduces two novel methods to incorporate DBCO into S. aureus peptidoglycan for SPAAC-mediated cargo labeling, showing improved stability and reduced toxicity compared to existing approaches.

Localized delivery of corticosteroids via in situ modification of gut commensals using a synthetic stem peptide prodrug

This paper develops a prodrug system for targeted colonic delivery of budesonide using gut commensals, showing improved drug localization and reduced systemic side effects.

A TLR7 Agonist Conjugated to a Nanofibrous Peptide Hydrogel as a Potent Vaccine Adjuvant

This paper conjugates a TLR7 agonist to a peptide hydrogel to create a vaccine adjuvant that produces antibody titers similar to alum and a more balanced Th1/Th2 immune response.

Intra-Lymph Node Crosslinking of Antigen-Bearing Polymers Enhances Humoral Immunity and Dendritic Cell Activation

This paper describes a novel vaccination platform using crosslinking polymers to enhance humoral immunity and dendritic cell activation in lymph nodes without adjuvants.