Changwan Chen

This study investigates brainwide dopamine dynamics across sleep-wake transitions in mice using fiber photometry and EEG/EMG, revealing region-specific changes and network correlations.

The paper identifies a brainstem circuit involving the nucleus of the solitary tract and parabrachial nucleus that mediates sickness-induced sleep by reducing norepinephrine release.

The paper shows that activating locus coeruleus noradrenergic neurons increases sleep propensity after wakefulness, indicating their role in sleep pressure through functional fatigue.