Science AdvancesNeurosciencePeer-reviewed journal article
Activation of locus coeruleus noradrenergic neuronsrapidly drives homeostatic sleep pressure
Daniel SilvermaniD, Changwan CheniD, Shuang ChangiD, Lillie Bui, Yufan ZhangiD, Rishi RaghavaniD, Anna Jiang, April N. Le, Dana M. DarmohrayiD, Jiao SimaiD, Xinlu Ding, Bing LiiD, Chenyan MaiD, Yang DaniD
Abstract
Homeostatic sleep regulation is essential for optimizing the amount and timing of sleep, but the underlying mechanism remains unclear. Optogenetic activation of locus coeruleus noradrenergic neurons immediately increased sleep propensity following transient wakefulness. Fiber photometry showed that repeated optogenetic or sensory stimulation caused rapid declines of locus coeruleus calcium activity and noradrenaline release. This suggests that functional fatigue of noradrenergic neurons, which reduces their wake-promoting capacity, contributes to sleep pressure.
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