Jiao Sima

Brainstem circuit for sickness-induced sleep

The paper identifies a brainstem circuit involving the nucleus of the solitary tract and parabrachial nucleus that mediates sickness-induced sleep by reducing norepinephrine release.

Activation of locus coeruleus noradrenergic neuronsrapidly drives homeostatic sleep pressure

The paper shows that activating locus coeruleus noradrenergic neurons increases sleep propensity after wakefulness, indicating their role in sleep pressure through functional fatigue.

Restoration of locus coeruleus noradrenergic transmission during sleep

The paper shows that noradrenaline transmission from the locus coeruleus decreases with wakefulness and recovers during sleep, with mTOR signaling involved in recovery.

Local rewiring of genome - nuclear lamina interactions by transcription.

The paper investigates how gene activation affects nuclear lamina interactions and shows that transcription can locally rewire these interactions without broadly altering chromosomal regions.

Identification of cis elements for spatio-temporal control of DNA replication

The paper identifies cis-regulatory elements (ERCEs) that control domain-wide replication timing, chromatin compartmentalization, and transcription in mouse embryonic stem cells.

Repli-seq: genome-wide analysis of replication timing by next-generation sequencing

This paper introduces a protocol and computational tools for genome-wide replication timing analysis using next-generation sequencing.