Dana M. Darmohray

Brainwide dopamine dynamics across sleep-wake transitions

This study investigates brainwide dopamine dynamics across sleep-wake transitions in mice using fiber photometry and EEG/EMG, revealing region-specific changes and network correlations.

Brainstem circuit for sickness-induced sleep

The paper identifies a brainstem circuit involving the nucleus of the solitary tract and parabrachial nucleus that mediates sickness-induced sleep by reducing norepinephrine release.

Activation of locus coeruleus noradrenergic neuronsrapidly drives homeostatic sleep pressure

The paper shows that activating locus coeruleus noradrenergic neurons increases sleep propensity after wakefulness, indicating their role in sleep pressure through functional fatigue.

Restoration of locus coeruleus noradrenergic transmission during sleep

The paper shows that noradrenaline transmission from the locus coeruleus decreases with wakefulness and recovers during sleep, with mTOR signaling involved in recovery.

Cannabinoids modulate associative cerebellar learning via alterations in behavioral state

This study shows that CB1 receptor deletion affects cerebellar learning indirectly through altered behavioral state rather than direct synaptic plasticity effects.

Shared and specific signatures of locomotor ataxia in mutant mice

The paper compares locomotor coordination impairments in two mouse mutants, finding shared and specific gait ataxia signatures.

Spatial and temporal locomotor learning in mouse cerebellum

This study shows that mice adapt to split-belt treadmill walking similarly to humans, revealing conserved locomotor learning mechanisms and distinct neural circuits for spatial and temporal adaptation components.