Author

Florian Kabinger

Broad InstituteORCID 0000-0002-3053-8253Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Amruth Kumar· 1 shared Anastasiia ChabaniD· 1 shared André Richters· 1 shared Angela N. KoehleriD· 1 shared Ann-Sophie Koglin· 1 shared Brain Bae· 1 shared Charles A. WhittakeriD· 1 shared Christopher J. OttiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Amruth Kumar

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2 papers

Recent·Most cited

Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network

Mohammed A. Toure, Keisuke Motoyama, Yichen Xiang, Julie Urgiles, Florian Kabinger, Ann-Sophie Koglin, Ramya S. Iyer, Kaitlyn Gagnon, Amruth Kumar, Samuel Ojeda, Drew A. Harrison, Matthew G. Rees, Jennifer A. Roth, Christopher J. Ott, Richard P. Schiavoni, , Angela N. Koehler

This study shows that CDK9 degradation with KI-CDK9d-32 is more effective than inhibition in disrupting MYC transcriptional networks and causes MYC downregulation and nucleolar destabilization.

Cell chemical biology · Mar 29, 2025Peer-reviewedCancer Biology

Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail

Anastasiia Chaban, Минахин Леонид Станиславович, Ekaterina Goldobina, Brain Bae, Yue Hao, Sergei I. Borukhov, Leena Putzeys, Maarten Boon, Florian Kabinger, Rob Lavigne, Kira S. Makarova, Eugene V. Koonin, Satish K. Nair, Shunsuke Tagami, Konstantin Severinov, Maria L. Sokolova

The paper identifies and characterizes two RNA polymerases in a thermophilic virus, showing their structural and functional differences and evolutionary origin.

Nature Communications · Jan 5, 2024Peer-reviewedMolecular Biology