Author

Lu Zhang

Chinese Academy of SciencesORCID 0000-0002-8640-1301Unclaimed ORCID profile · follow to get notified of new preprints

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Lu Zhang11 papers · Chinese Academy of Sciences

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Organism:E. coli· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

Adrian Deng· 1 shared Benny Zhibin Liang· 1 shared Billy Wai-Lung Ng· 1 shared Buyu Zhang· 1 shared Carmen Ka Man TseiD· 1 shared Danielle Groves· 1 shared Daqi YuiD· 1 shared Elena V. SinevaiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperMicrobiology

Adrian Deng

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3 papers

Recent·Most cited

Nucleobase Methylation Enhances SARS-CoV-2 Chain Terminator Evasion of Exonuclease Proofreading

Lin Yang, Rory Cunnison, Carmen Ka Man Tse, Tiantian Xu, Buyu Zhang, Rick Xinzhou Xu, Benny Zhibin Liang, Xunyu Zhou, Danielle Groves, Adrian Deng, Jeremy R Keown, Daqi Yu, Mingyuan Li, Yuanliang Zhai, Billy Wai-Lung Ng, , Peter Pak‐Hang Cheung

This study identifies 5-methyl-3'-dUTP as a nucleoside analogue that effectively terminates RNA chains and resists SARS-CoV-2 exoribonuclease proofreading.

bioRxiv · Sep 20, 2024 · PreprintMicrobiology

AB-Gen: Antibody Library Design with Generative Pre-trained Transformer and Deep Reinforcement Learning

Xiaopeng Xu, Tiantian Xu, Juexiao Zhou, Xingyu Liao, Ruochi Zhang, Yu Wang, Lu Zhang, Xin Gao

AB-Gen uses reinforcement learning and a generative pre-trained Transformer to design antibody sequences with multiple desirable properties, improving success rates over traditional methods.

Genomics Proteomics & Bioinformatics · Jun 24, 2023Peer-reviewedBioinformatics

Allosteric effector ppGpp potentiates the inhibition of transcript initiation by DksA

Vadim Molodtsov, Elena V. Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah E. Ades, Katsuhiko S. Murakami

This study reports the X-ray crystal structures of E. coli RNA polymerase complexes with DksA and ppGpp, revealing how ppGpp enhances DksA's inhibition of transcription initiation.

Molecular Cell · Feb 22, 2018Peer-reviewedMolecular Biology