J. Monty Watkins

Assessing the Suitability of Deubiquitylases As Substrates For Targeted Protein Degradation

This study evaluates whether deubiquitylases (DUBs) can be effectively degraded by PROTACs, finding that some DUBs are degradable while others resist degradation due to auto-deubiquitylation or poor proteasome substrate properties.

MERS-CoV antagonizes PKR activation by inhibiting its condensation at viral replication complexes

This study shows MERS-CoV inhibits PKR activation by blocking its condensation on viral dsRNA, revealing a mechanism by which the virus evades innate immune responses.

RNase L regulates the antiviral proteome by accelerating mRNA1decay, inhibiting nuclear mRNA export, and repressing RNAPII-2mediated transcription

This study shows RNase L reduces antiviral proteins by inhibiting mRNA export and RNAPII-mediated transcription during flavivirus infection.

RNase L-induced bodies sequester subgenomic flavivirus RNAs and re-establish host RNA decay

The paper shows that RNase L-induced bodies sequester subgenomic flavivirus RNAs, reducing their interaction with P-bodies and enhancing viral RNA decay.