Simone Albani

Functional analysis of ligand-gated chloride channels in a cnidarian sheds light on the evolution of inhibitory signalling

The paper functionally analyzes ligand-gated chloride channels in cnidarians, finding that some use glutamate instead of GABA for inhibitory signaling, suggesting early diversification of inhibitory receptors.

Computational screening and automatic filtering for the discovery of novel inhibitors of TMPRSS2, a type II transmembrane serine protease

The paper uses structure-based virtual screening to identify novel TMPRSS2 inhibitors from a large compound library, selecting 10 hit candidates through a reproducible filtering workflow.

Depletion of membrane cholesterol modifies structure, dynamic and activation of Nav1.7

This study shows that cholesterol depletion alters Nav1.7 structure and function, affecting its gating and drug response, with implications for pain management.

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

The paper identifies 62 new inhibitors of SARS-CoV-2 3CL-Pro through a compound repurposing screen and validates their activity using X-ray crystallography.