Extracellular vesicles from morphine-exposed prefrontal cortex carry transcriptomic and proteomic signatures of synaptic dysfunction
Pedro Henrique Gobira, Sávio Bastos, Rachele Rossi, Christian Bjerggaard Vægter, Fenghua Chen, Nicole Rodrigues da Silva, Heidi Kaastrup Müller, Sâmia R.L. Joca, Thomas P. Boesen, Thiago Wendt Viola, Yan Yan, Martin R. Larsen, Victor Corasolla Carregari, Rodrigo Grassi‐Oliveira
This study shows that chronic morphine exposure alters the transcriptomic and proteomic content of brain-derived extracellular vesicles from the prefrontal cortex, which can reprogram recipient neurons.
bioRxiv · Sep 12, 2025 · PreprintNeuroscience