Rodrigo Grassi‐Oliveira

This study shows prenatal THC exposure reduces metabolic gene expression and KEAP1 in mouse placental labyrinth, while CBD has no significant effect.

Across 15 cohorts (birth to 24 years), 20 epigenetic clocks and eight brain age models predicted chronological age modestly, stabilizing by middle childhood; their age residuals were weakly associated.

This study shows that chronic morphine exposure alters the transcriptomic and proteomic content of brain-derived extracellular vesicles from the prefrontal cortex, which can reprogram recipient neurons.

This study isolates extracellular vesicles from postmortem brain tissue and uses multi-omics analysis to identify lipidomic and proteomic changes associated with substance use disorder.

This study finds that chronic cocaine users show altered sensitivity to gain information during risky decision-making, leading to increased risk-seeking in unfavorable scenarios.

This study shows that m6dA accumulation in DNA of prefrontal cortical neurons is linked to fear extinction learning and gene expression.