Lorenzo Giordani

CD90 identifies distinct fractions of muscle stem cells with different modalities of activation and quiescence maintenance

The paper identifies CD90 as a marker distinguishing two muscle stem cell subpopulations with different activation kinetics and quiescence maintenance mechanisms in mice and humans.

Axonopathy in Duchenne Muscular Dystrophy limits microdystrophin gene therapy efficacy

This study shows that axonopathy in DMD limits microdystrophin gene therapy efficacy by demonstrating that dystrophin is expressed in peripheral nerves and its absence causes nerve structural collapse and impaired nerve-muscle connectivity.

GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD

This study shows that GDF5 overexpression in DMD mdx mice improves muscle histology, reduces inflammation, and enhances microdystrophin gene therapy outcomes.

Spatial and Multiomic profiling of muscle regeneration dynamics in Duchenne Muscular Dystrophy

This study identifies NOTCH3 and GLIS3 as contributors to regeneration impairment in Duchenne Muscular Dystrophy using spatial transcriptomics and multiomic profiling.

Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle

The paper uses spatially resolved transcriptomics to identify innervation-responsive functional clusters in skeletal muscle and shows changes in atrophic signaling and polyamine metabolism upon denervation.