Thorsten Kahnt

Reactivation during sleep segregates the neural representations of episodic memories

The paper shows that reactivation during sleep reduces overlap between neural representations of contextually linked memories, promoting object and context specificity.

Neurometabolic signatures of addiction vulnerability and heroin versus social seeking: a PET study in rats

This study identifies neurometabolic differences in rats associated with heroin addiction vulnerability and social seeking using FDG-PET imaging and behavioral assays.

Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior

This study shows that anterior and posterior orbitofrontal cortex subregions support different aspects of outcome-guided behavior: learning stimulus-outcome associations and inferring current option values.

Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus

This study shows that dopamine neuron prediction error signaling for reward value and identity depends differently on the hippocampus and orbitofrontal cortex in rats.

Expectancy-related changes in firing of dopamine neurons depend on hippocampus

This study shows that hippocampal lesions affect dopamine neuron firing patterns during a reward prediction task, contrasting with the role of the orbitofrontal cortex.

Opioid antagonism reduces wanting by strengthening frontostriatal connectivity

This study shows that opioid antagonism reduces reward wanting by enhancing frontostriatal connectivity in humans.

Enhanced reinstatement of naturalistic event memories due to hippocampal-network-targeted stimulation

This study shows that stimulating the hippocampal network enhances the reinstatement of naturalistic event memories in humans, improving memory accuracy.

Targeted stimulation of an orbitofrontal network disrupts decisions based on inferred, not experienced outcomes

This study shows that stimulating the orbitofrontal cortex impairs decision-making based on inferred outcomes but not on direct experience.

Targeted stimulation of human orbitofrontal networks disrupts outcome-guided behavior

This study uses cTBS to disrupt human OFC network activity and shows impaired outcome-guided behavior after reward devaluation.

Dopamine neuron ensembles signal the content of sensory prediction errors

The paper shows that groups of dopamine neurons in rats and human midbrain signal specific sensory prediction errors through ensemble firing patterns.