Yavin Shaham

Focal transcranial magnetic stimulation of the rat anterior cingulate cortex reduced relapse-like behavior and restored corticostriatal connectivity during opioid abstinence.

This study examines dopamine dynamics in the nucleus accumbens during positive and negative reinforcement in rats, finding distinct patterns for different reinforcer types and availability.

Focal transcranial magnetic stimulation of the medial prefrontal cortex prevents cocaine craving incubation and restores functional connectivity in a rat model of relapse.

This study identifies neurometabolic differences in rats associated with heroin addiction vulnerability and social seeking using FDG-PET imaging and behavioral assays.

This study shows that heroin relapse triggered by drug cues persists for over a year in abstinent rats, indicating long-term vulnerability to opioid relapse.

The paper identifies a whole-brain functional connectivity pattern that predicts individual differences in opioid craving incubation in rats after abstinence.

This study shows chronic buprenorphine reduces heroin seeking incubation and decreases neuronal activation in specific brain regions in rats.

The paper shows that distinct prelimbic cortex ensembles encode response execution and inhibition during different phases of operant learning in rats.

This study examines neural activity in the basolateral and central amygdala during reward seeking under punishment, finding that opposing neuronal populations in the CeA control reward-seeking behavior despite adverse consequences.

This study maps the anatomical connections and activation patterns of the dorsomedial nucleus accumbens (dmACB) and finds reduced dmACB activation correlates with increased opioid seeking after abstinence.

This study introduces a CRISPR-based Oprm1-Cre knock-in rat to investigate the role of nucleus accumbens MOR-expressing cells in heroin self-administration, finding sex-specific effects on acquisition and effort.

This study shows that ventral subiculum neuronal ensembles are specifically involved in the incubation of oxycodone craving after voluntary abstinence, but not after forced abstinence or early abstinence.

The paper establishes a mouse model of incubation of palatable food craving and identifies brain-wide activation patterns using whole-brain activity mapping.

The paper examines individual differences in addiction-like behaviors and cocaine versus food choice in Heterogeneous Stock rats, finding that high addiction score rats show increased cocaine preference after recent cocaine use.

This study shows that pain-related manipulations in rats do not increase opioid self-administration, reinstatement of seeking, or choice over food.

This study investigates DS-controlled incubation of cocaine craving in rats, finding that cocaine-seeking behavior increases over abstinence, unlike food-seeking behavior.