Geoffrey M. Schoenbaum

This study examines dopamine dynamics in the nucleus accumbens during positive and negative reinforcement in rats, finding distinct patterns for different reinforcer types and availability.

This study shows that prior cocaine use impairs the orbitofrontal cortex's ability to identify hidden states during a task, leading to reduced generalization and increased behavioral variability.

This study shows that persistent representation of a prior schema in the orbitofrontal cortex supports learning of a conflicting schema in rats.

The paper describes the generation of a tamoxifen-inducible Cre driver rat for microglial transgene expression and validates its specificity and functionality.

This study shows that anterior and posterior orbitofrontal cortex subregions support different aspects of outcome-guided behavior: learning stimulus-outcome associations and inferring current option values.

The paper shows that distinct prelimbic cortex ensembles encode response execution and inhibition during different phases of operant learning in rats.

This study shows that dopamine neuron prediction error signaling for reward value and identity depends differently on the hippocampus and orbitofrontal cortex in rats.

This study uses computational modeling and optogenetics to show that dopamine neuron stimulation promotes learning, supporting the prediction error hypothesis over the rewarding value hypothesis.

This study examines neural activity in the basolateral and central amygdala during reward seeking under punishment, finding that opposing neuronal populations in the CeA control reward-seeking behavior despite adverse consequences.

The paper examines dopamine and acetylcholine correlations in the nucleus accumbens during a behavioral task in rats, finding their relationship varies based on task phases.

This study investigates how dopamine and acetylcholine dynamics change during learning in rats, finding that acetylcholine signals evolve sequentially and complement dopamine in determining learning content and rate.

This study shows that prior cocaine use changes neural ensemble representations in the orbitofrontal cortex, affecting decision-making in rats.

This study investigates cue reactivity in dopamine neurons after opioids, finding that drug and natural reward cues elicit similar enhanced responses, challenging existing hypotheses about dopamine's role in relapse.

This study shows that the D3R antagonist VK4-116 improves behavioral flexibility in rats with a history of cocaine use during abstinence.

This study shows dopamine signals prediction errors during both latent learning of value-neutral cues and reward-based conditioning, suggesting a domain-general role in model-based learning.

This study shows that hippocampal lesions affect dopamine neuron firing patterns during a reward prediction task, contrasting with the role of the orbitofrontal cortex.

This study investigates how hippocampal output affects schema formation in orbitofrontal cortex, finding that inactivation during learning accelerates schema correlates while post-learning inactivation has no effect, supporting a parallel model of cognitive map formation.

The paper investigates the role of the orbitofrontal cortex in creating cognitive maps by showing that its inactivation disrupts specific cue-outcome associations but not model-based learning overall.

This study investigates the role of the orbitofrontal cortex in learning state transitions, finding that OFC activity correlates with more optimal predictions rather than simple prediction errors.

This study identifies prospective coding in rat orbitofrontal cortex for predicting future outcomes during an odor sequence task.

This paper validates the neural representations of Deep RL agents against animal neural data, showing similar geometry in latent spaces and the role of temporal information.

This study shows that stimulating the orbitofrontal cortex impairs decision-making based on inferred outcomes but not on direct experience.

This paper shows that orbitofrontal cortex activity during cue preconditioning is necessary for value inference in probe tests, indicating it encodes associative information beyond value.

The paper provides causal evidence that dopamine transients from reward-predictive cues function as prediction errors by showing their role in second-order conditioning.

This study uses cTBS to disrupt human OFC network activity and shows impaired outcome-guided behavior after reward devaluation.

This study shows that dopamine transients in learning contexts do not create cached value but instead support valueless associative learning.

The paper shows that groups of dopamine neurons in rats and human midbrain signal specific sensory prediction errors through ensemble firing patterns.

This study shows that rat orbitofrontal cortex activity represents both a value-invariant task structure and expected value during an odor sequence task.

This paper proposes a new theory of dopamine function that extends prediction error to include sensory predictions, bridging model-based and model-free reinforcement learning.