Liu Y

Targeting NAT10 Activates Tumor-Intrinsic Immunity and Suppresses Tumor Progression in Head and Neck Squamous Cell Carcinoma

This study identifies NAT10 as a suppressor of tumor-intrinsic immunity in HNSCC, showing that its inhibition enhances immune responses and suppresses tumor progression.

Seeing the world in a grain of sand: Fine global and local representations in foveal and parafoveal vision

The paper shows that fine-global form and fine-local detail are processed in parallel in V1 and preserved through the ventral visual stream for both foveal and parafoveal vision.

Spalt-related is an integrated stress response-activated inhibitor of mTORC1-mediated growth

This study identifies Spalt-related (Salr) as a negative regulator of growth and lipid storage, activated through the integrated stress response and converging with FoxO to promote catabolism during nutrient stress.

Field–Flow–Front mapping of breast cancer evolutionary dynamics in situ

This paper maps breast cancer evolution in situ using spatial transcriptomics and other data to show that tumor progression is driven by spatially coherent fronts rather than predefined clonal branches.

DNA-binding specificity recognition from predicted homologous protein-DNA structures

This paper introduces HomoDSP, a method for DNA-binding specificity prediction using homologous protein-DNA structures, showing improved accuracy and generalization over existing methods.

Super-Resolved Single Small Extracellular Vesicle Assay enabled by a Plasmonic Nanohole Array

This paper introduces a nanoplasmonic platform for high-resolution single small extracellular vesicle quantification and subpopulation differentiation, achieving a detection limit of 143 sEVs/μL.

Telomeric heterochromatin acts in trans to promote meiotic centromere assembly via Aurora B kinase recruitment

The paper shows telomeric heterochromatin promotes meiotic centromere assembly by recruiting Aurora B kinase through Swi6HP1 and Haspin-dependent phosphorylation of centromere proteins.

Efficient and accurate near telomere-to-telomere haplotype reconstruction of diploid genomes

HapFold improves haplotype reconstruction for diploid genomes by combining graph-based and sequence-based scaffolding methods, achieving high accuracy and contiguity.

FluNexus: a versatile web platform for antigenic prediction and visualization of influenza A viruses

FluNexus provides a web platform for antigenic prediction and visualization of influenza A viruses, offering tools for data preprocessing, prediction, and visualization of antigenic evolution.