Author

Maria Virginia Soldovieri

University of MoliseORCID 0000-0002-3601-9374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1

Frequent Co-Authors

Maurizio TaglialatelaiD· 2 shared Agnese RoscioniiD· 1 shared Alessandro BerselliiD· 1 shared Ana Luı́sa CarvalhoiD· 1 shared Ângela S. InácioiD· 1 shared Annie Ting Gee ChiuiD· 1 shared Fabio BenfenatiiD· 1 shared Francesco MiceliiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

Maurizio TaglialatelaORCID

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2 papers

Recent·Most cited

CONSTITUTIVE OPENING OF THE Kv7.2 PORE ACTIVATION GATE CAUSES KCNQ2-DEVELOPMENTAL ENCEPHALOPATHY

Mario Nappi, Giulio Alberini, Alessandro Berselli, Agnese Roscioni, Maria Virginia Soldovieri, Ilenio Servettini, Vincenzo Barrese, Sarah Weckhuysen, Annie Ting Gee Chiu, Ingrid Eileen Scheffer, Fabio Benfenati, Luca Maragliano, Francesco Miceli, Maurizio Taglialatela

This study identifies two KCNQ2 variants causing developmental encephalopathies by constitutively opening the Kv7.2 pore activation gate, leading to gain-of-function effects.

Proceedings of the National Academy of Sciences · Nov 27, 2024Peer-reviewedBiophysics

Type I TARPs regulate Kv7.2 potassium channels andsusceptibility to seizures

Marina Manuela Ventura Rodrigues, Ângela S. Inácio, Maria Virginia Soldovieri, Sara Ribau, Telmo M. Leal, Theo Baurberg, Ilaria Mosca, Paolo Ambrosino, Luísa Amado, Nuno Beltrão, Gladys L. Caldeira, Luís F. Ribeiro, Ka Wan Li, Laurent Groc, Joana S. Ferreira, , Ana Luı́sa Carvalho

This study identifies type I TARPs as regulators of Kv7.2 potassium channels and shows their role in modulating neuronal excitability and seizure susceptibility.

bioRxiv · Aug 9, 2024 · PreprintNeuroscience