Author

Yi-Lin Cheng

Goethe University FrankfurtORCID 0000-0002-3603-5913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Ivan ĐikićiD· 2 shared Adriana Covarrubias‐PintoiD· 1 shared Ahmad Reza MehdipouriD· 1 shared Alexis GonzáleziD· 1 shared Anshu BhattacharyaiD· 1 shared Christian Andreas HübneriD· 1 shared Chun KewiD· 1 shared Donghyuk Shin· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Ivan ĐikićORCID

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2 papers

Recent·Most cited

Intracellular lipopolysaccharide binds RETREG1/FAM134B to regulate ER remodeling upon bacterial infection

Yi‐Lin Cheng, João Mello-Vieira, Adriana Covarrubias‐Pinto, Alexis González, Santosh Kumar Kuncha, Chun Kew, K. Zhang, Muhammad Awais Afzal, Nour Diab, Sophia Borchert, Siou-Ying Hong, Timothy Chun Huang, Wenbo Chen, Uxía Gestal Mato, Mathias Walter Hornef, , Ivan Đikić

This study shows that bacterial LPS binds RETREG1 to induce ER remodeling and enhance antibacterial defense through ERphagy.

Autophagy · May 12, 2026Peer-reviewedCell Biology

Novel class of OTU deubiquitinases regulate substrate ubiquitinationupon Legionella infection

Donghyuk Shin, Anshu Bhattacharya, Yi-Lin Cheng, Marta Campos Alonso, Ahmad Reza Mehdipour, Gerbrand J. van der Heden van Noort, Huib Ovaa, Gerhard Hummer, Ivan Đikić

The paper identifies two novel Legionella OTU-like deubiquitinases, LotB and LotC, and describes their structural and functional differences in ubiquitin chain cleavage during infection.

bioRxiv · Apr 25, 2020 · PreprintMolecular Biology