Wenhao O. Ouyang

Characterization of two non-competing antibodies to influenza H3N2 hemagglutinin stem reveals its evolving antigenicity

This study characterizes two non-competing group 2 influenza HA stem antibodies and shows their in vivo protective efficacy despite limited in vitro neutralization.

High-throughput synthesis and specificity characterization of natively paired antibodies using oPool+ display

This study introduces oPool+ display, a high-throughput platform for synthesizing and characterizing natively paired antibodies, demonstrating its application in analyzing influenza HA antibodies.

A library-on-library screen reveals the breadth expansion landscape of a broadly neutralizing betacoronavirus antibody

This study uses a library-on-library approach to analyze how a betacoronavirus antibody evolves breadth through somatic hypermutations, identifying key mutations that improve binding across multiple antigenic variants.