Tossapol Pholcharee

Antibodies targeting a conserved cryptic epitope at the influenza hemagglutinin head-stem interface via distinct binding modes

This study characterizes two broadly reactive antibodies against a conserved cryptic epitope at the influenza HA head-stem interface, showing they are non-neutralizing and have limited protective efficacy.

TRIM21 is a molecular rheostat for influenza A virus replication

This study shows TRIM21 acts as a molecular rheostat regulating influenza A virus replication by modulating ubiquitination and innate immune signaling, with PRKDC as a compensatory antiviral factor when TRIM21 is absent.

Structural insights into antibody responses against influenza A virus in its natural reservoir

This study characterizes antibody responses to H3 influenza A virus in mallard ducks, revealing unique features compared to human antibodies and highlighting gene conversion in antibody evolution.

Characterization of two non-competing antibodies to influenza H3N2 hemagglutinin stem reveals its evolving antigenicity

This study characterizes two non-competing group 2 influenza HA stem antibodies and shows their in vivo protective efficacy despite limited in vitro neutralization.

Structure basis for distinct protective mechanisms of IGHV3-23 antibodies targeting influenza hemagglutinin stem

This study identifies three IGHV3-23 antibodies targeting influenza HA stem, showing that non-neutralizing antibodies with enhanced Fc-mediated effector functions offer better in vivo protection than a potent neutralizer.

Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline

This study identifies an antibody that cross-reacts with H5N1 and H3N2 neuraminidases and shows how somatic hypermutation enables this cross-reactivity.

High-throughput synthesis and specificity characterization of natively paired antibodies using oPool+ display

This study introduces oPool+ display, a high-throughput platform for synthesizing and characterizing natively paired antibodies, demonstrating its application in analyzing influenza HA antibodies.

Structure-guided design of a Plasmodium vivax Duffy binding protein-based vaccine immunogen

This study designs an improved PvDBP-based immunogen using structure-guided methods to enhance its stability and antibody response against Plasmodium vivax.