Akshita Baiju Gopal

Mutational fitness landscapes of diverse human influenza H1N1 neuraminidases

This study quantifies the replication fitness effects of mutations in diverse H1N1 influenza neuraminidases, revealing strain-dependent effects and epistasis patterns.

Somatic evolution of a cross-reactive germline antibody that expands its breadth to neutralize new SARS-CoV-2 variants

This study identifies a cross-reactive germline antibody that can be evolved to neutralize multiple SARS-CoV-2 variants through targeted somatic mutations.

Structural insights into antibody responses against influenza A virus in its natural reservoir

This study characterizes antibody responses to H3 influenza A virus in mallard ducks, revealing unique features compared to human antibodies and highlighting gene conversion in antibody evolution.

Characterization of two non-competing antibodies to influenza H3N2 hemagglutinin stem reveals its evolving antigenicity

This study characterizes two non-competing group 2 influenza HA stem antibodies and shows their in vivo protective efficacy despite limited in vitro neutralization.

Structure basis for distinct protective mechanisms of IGHV3-23 antibodies targeting influenza hemagglutinin stem

This study identifies three IGHV3-23 antibodies targeting influenza HA stem, showing that non-neutralizing antibodies with enhanced Fc-mediated effector functions offer better in vivo protection than a potent neutralizer.

Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline

This study identifies an antibody that cross-reacts with H5N1 and H3N2 neuraminidases and shows how somatic hypermutation enables this cross-reactivity.

High-throughput synthesis and specificity characterization of natively paired antibodies using oPool+ display

This study introduces oPool+ display, a high-throughput platform for synthesizing and characterizing natively paired antibodies, demonstrating its application in analyzing influenza HA antibodies.

Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model

This study examines how immune history affects antibody responses to influenza H1N1 hemagglutinin and neuraminidase in mice, finding that HA responses are more restricted by prior infection than NA responses.