Author

Nicole E. Félix Vélez

University of California San DiegoORCID 0000-0002-3637-1992Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Brian A. AguadoiD· 4 shared Rayyan M. GorashiiD· 3 shared Ryan Robert ReevesiD· 2 shared Ashley K. NguyeniD· 1 shared Brandon J. VogtiD· 1 shared Brisa PeñaiD· 1 shared Kristi S. AnsethiD· 1 shared Kristi Tu· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBioengineering

Brian A. AguadoORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

BioengineeringCell ReportsPeer-reviewedJul 1, 2026

Circulating biomarkers in serum from aortic valve stenosis patients predict sex-specific drug responses in valve myofibroblasts

Brandon J. Vogt, Megan Chavez, Nicole E. Félix Vélez…·Lonnie D. Shea

The paper identifies IGFBP2 as a sex-specific serum biomarker predicting Evogliptin resistance in female aortic valve stenosis patients.

2 citationstop 2%

humanproteomics

𝕏 PostBluesky

BioengineeringCellular and Molecular BioengineeringPeer-reviewedJun 22, 2026

Transforming Growth Factor β1 Modulates Sex Differences in Cardiac Myofibroblast Activation on Hydrogel Biomaterials

Mason N Faust, Ashley K. Nguyen, Rayyan M. Gorashi…·Brian A. Aguado

This study shows TGF-β1 causes sex-specific cardiac myofibroblast activation and secreted factor differences on hydrogels, influencing fibrosis.

3 citationstop 1%

mouseproteomics

𝕏 PostBluesky

BioengineeringScience AdvancesPeer-reviewedMar 12, 2025

Y chromosome linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues

Rayyan M. Gorashi, Talia Baddour, Sarah J. Chittle…·Brian A. Aguado

The paper investigates how UTY modulates sex-specific methylation in male valvular fibroblasts in response to nanoscale extracellular matrix cues, promoting osteoblast-like cell phenotypes in aortic valve stenosis.

19 citationstop 1%

humanDNA methylation

𝕏 PostBluesky

BioengineeringJournal of Biomedical Materials Research Part APeer-reviewedFeb 24, 2025

Secreted cytokines from inflammatory macrophages modulate sex differences in valvular interstitial cells on hydrogel biomaterials

Nicole E. Félix Vélez, Kristi Tu, Peng Guo…·Brian A. Aguado

The paper investigates how inflammatory cytokines from macrophages differentially affect male and female valvular interstitial cells on hydrogel biomaterials, revealing sex-specific mechanisms in myofibroblast activation and osteoblast-like differentiation.

18 citationstop 1%

humanexperimental assay

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