Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer
Frédéric Fercoq, Gemma S. Cairns, Victoria Louise Bridgeman, Marco De Donatis, John B. G. Mackey, Alessia Floerchinger, Amanda J. McFarlane, Judith Secklehner, Ximena L. Raffo Iraolagoitia, Madeline Harrington, Lynn McGarry, Demi Brownlie, Declan Whyte, Lindsey W. G. Arnott, Colin Nixon, , Leo M. Carlin
This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.
Cell Reports · Mar 1, 2026Peer-reviewedImmunology