YY1 relieves p300 autoinhibition to promote histone acetylation in advanced prostate cancer, enhancing the oncogenic signaling of Androgen Receptor Splice Variant 7
Chenxi Xu, Dongyu Wu, Bo Pan, Xiaoxiao Ren, Samuel G. Mackintosh, Kanishk Jain, Natarajan V. Bhanu, Ricky D. Edmondson, Xin Liu, Benjamin Aaron Garcia, Alan J. Tackett, Jian Jun Jin, Gang Greg Wang, Ling Cai
This study shows YY1 enhances p300 acetyltransferase activity in CRPC, promoting histone acetylation and oncogenic gene expression, and identifies a potential therapeutic target for overcoming drug resistance.
bioRxiv · Aug 4, 2025 · PreprintCancer Biology