Author

Ling Cai

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Gang Greg WangiD· 2 shared Alan J. TackettiD· 1 shared Benjamin Aaron GarciaiD· 1 shared Bo PaniD· 1 shared Brian D. StrahliD· 1 shared Brittany Detrick· 1 shared Burak Çetin· 1 shared Chenxi XuiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Gang Greg WangORCID

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2 papers

Recent·Most cited

YY1 relieves p300 autoinhibition to promote histone acetylation in advanced prostate cancer, enhancing the oncogenic signaling of Androgen Receptor Splice Variant 7

Chenxi Xu, Dongyu Wu, Bo Pan, Xiaoxiao Ren, Samuel G. Mackintosh, Kanishk Jain, Natarajan V. Bhanu, Ricky D. Edmondson, Xin Liu, Benjamin Aaron Garcia, Alan J. Tackett, Jian Jun Jin, Gang Greg Wang, Ling Cai

This study shows YY1 enhances p300 acetyltransferase activity in CRPC, promoting histone acetylation and oncogenic gene expression, and identifies a potential therapeutic target for overcoming drug resistance.

bioRxiv · Aug 4, 2025 · PreprintCancer Biology

Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation

Wendan Ren, Huitao Fan, Sara A. Grimm, Yiran Guo, Jae Jin Kim, Jiekai Yin, Linhui Li, Christopher J. Petell, Xiao-Feng Tan, Zhimin Zhang, John P. Coan, Linfeng Gao, Ling Cai, Brittany Detrick, Burak Çetin, , Jikui Song

This study identifies the RFTS domain of DNMT1 as a reader for H3K9me3/H3Ub, showing its role in DNA methylation maintenance and genomic stability.

Proceedings of the National Academy of Sciences · Jul 16, 2020Peer-reviewedGenetics