Samuel F. H. Barnett

This paper identifies how CDKL5 is anchored at the postsynaptic density via interactions with PDZ domains and talin, and shows that its spatial positioning is regulated by talin's mechanical properties.

This paper introduces SiLM, a chip-based 3D single-molecule localization microscopy method that achieves high axial precision with a single-objective lens, comparable to 4Pi methods.

This paper introduces a single-construct optogenetic tool to control talin dimerization, enabling precise manipulation of mechanotransduction in integrin-based adhesions.

The paper introduces the MeshCODE model to visualize synaptic binary information through structural analysis of talin and vinculin scaffolding proteins.

ShareLoc provides an open platform for sharing and reanalyzing SMLM data to enhance image reconstruction through deep learning.