Author

Vignesh Srinivasan

University of Helsinki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Benjamin Thomas GoultiD· 2 shared Juha SaarikangasiD· 2 shared Neil J. BalliD· 2 shared Y OtaniiD· 2 shared Dan LindholmiD· 1 shared Emily GoodalliD· 1 shared Hans‐Jürgen KreienkampiD· 1 shared Igor BarsukoviD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersNeuroscience

Benjamin Thomas GoultORCID

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3 papers

Recent·Most cited

An internal PDZ-binding motif in Densin-180 promotes activity-dependent SHANK scaffold remodelling

Y Otani, Vignesh Srinivasan, Julia Töller, Till Kallem, Neil J. Ball, Igor Barsukov, Juha Saarikangas, Hans‐Jürgen Kreienkamp, Benjamin Thomas Goult

This study identifies an internal PDZ-binding motif in Densin-180 that promotes SHANK scaffold remodelling through activity-dependent interactions.

bioRxiv · Jul 10, 2026 · PreprintNeuroscience

Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains

Y Otani, Emily Goodall, Vignesh Srinivasan, Neil J. Ball, Samuel F. H. Barnett, Tobias Zech, Juha Saarikangas, Benjamin Thomas Goult

This paper identifies how CDKL5 is anchored at the postsynaptic density via interactions with PDZ domains and talin, and shows that its spatial positioning is regulated by talin's mechanical properties.

bioRxiv · Aug 27, 2025 · PreprintNeuroscience

USP14 regulates pS129 α-synuclein levels and oxidative stress in human SH-SY5Y dopaminergic cells

Vignesh Srinivasan, Rabah Soliymani, Larisa B. Ivanova, Ove Eriksson, Nina Peitsaro, Maciej M. Lalowski, Mati M. Karelson, Dan Lindholm

This study shows that USP14 regulates pS129 α-synuclein and oxidative stress in SH-SY5Y cells by affecting proteasome activity and reducing ROS.

bioRxiv · May 9, 2024 · PreprintNeuroscience