Tiong Kit Tan

This paper introduces Duality vaccination, a method that delivers both activating and inhibitory stimuli to shape antibody responses, using nanoparticle-based immunogens.

This paper introduces a method for continuous mass photometry of single molecules, enabling long-term observation of biomolecular interactions with high mass precision and temporal resolution.

This study identifies nanobodies targeting conserved SARS-CoV-2 RBD epitopes that neutralize variants and zoonotic sarbecoviruses.

This study directly observes and quantifies the self-assembly of virus-like particles using mass photometry and single-molecule trapping, revealing the role of multivalent interactions and first-passage dynamics in achieving specific assembly.

This paper develops a recombinant single-cycle influenza viral vector vaccine against SARS-CoV-2 and SARS-like betacoronaviruses, showing robust immune responses in mice.

This paper develops a single-cycle influenza vaccine, CLEARFLU, that induces neutralising antibodies to haemagglutinin and T-cell responses, offering broad and strain-specific protection.