Timothy J. Wendorff

This paper develops scalable human neuron models of Alzheimer's disease to reveal mechanisms linking Tau fibrillization to synaptic dysfunction and identifies therapeutic targets.

This paper introduces IMaP, a method to analyze tau proteoforms at the single-molecule level, revealing ordered phosphorylation patterns and disease-specific modifications.

The paper develops a scalable mutagenic base editor platform to identify drug-resistant variants in cancer genomes efficiently.