Xiwei Shan

Biosynthetic additive manufacturing through mycelium-bacteria consortia

This paper develops a biosynthetic additive manufacturing method using mycelium-bacteria consortia to convert lignocellulosic biomass into durable structural materials.

A scalable human neuron model of Alzheimer's disease relevant tauopathy reveals mechanisms linking Tau fibrillization to synaptic dysfunction

This paper develops scalable human neuron models of Alzheimer's disease to reveal mechanisms linking Tau fibrillization to synaptic dysfunction and identifies therapeutic targets.

Integrated morphological, multi-omics, and functional profiling reveals microglial plasticity driven by AD risk genes

This study identifies six microglial transcriptional profiles linked to specific morphological phenotypes and shows AD risk genes disrupt morpho-transcriptomic coupling and phagocytic capacity.

Direct RNA Sequencing reveals epitranscriptomic regulation of brain cells and Alzheimer's Disease pathology

This study uses direct RNA sequencing to analyze epitranscriptomic changes in brain cells, revealing m6A modification patterns linked to Alzheimer's disease progression.