Edit I. Buzás

Stress-induced switch in small extracellular vesicle secretion: from constitutive 'torn bag mechanism' to exocytosis

The paper identifies two sEV secretion mechanisms, showing that stress activates exocytosis of multivesicular endosomes while steady-state conditions use the 'torn bag mechanism'.

Cholesteryl esters and high protein-to-lipid ratios distinguish Non-Vesicular Extracellular Particles from Extracellular Vesicles

This paper identifies non-vesicular extracellular particles (167k-NVEPs) as a distinct class from EVs based on lipid composition, protein-to-lipid ratio, and size, with implications for disease biology and therapeutic delivery.

BeWo-derived extracellular vesicles downregulate IL-6Rα expression via miRNAs on CD4+ T lymphocytes

The paper shows BeWo-derived extracellular vesicles reduce IL-6Rα on CD4+ T cells via miRNAs, altering the IL-6 pathway and T cell function in vitro and correlating with pregnancy-associated IL-6R downregulation.

Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells

This study shows neural stem cells transfer functional mitochondria via extracellular vesicles to restore mitochondrial function in target cells, improving disease outcomes in multiple sclerosis.