Author

Luca Peruzzotti‐Jametti

University of CambridgeORCID 0000-0002-9396-5607Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Stefano PluchinoiD· 7 shared Alexandra M. NicaiseiD· 4 shared Cory M. WillisiD· 4 shared Tommaso LeonardiiD· 4 shared Christian FrezzaiD· 3 shared Aletta M.R. van den BoschiD· 2 shared Angelo D’AlessandroiD· 2 shared Carlo Fiore ViscomiiD· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersNeuroscience

Stefano PluchinoORCID

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

Rosana-Bristena Ionescu, Alexandra M. Nicaise, Julie A. Reisz, Eleanor C Williams, Pranathi Prasad, Cory M. Willis, Madalena B C Simões-Abade, Linda Sbarro, Monika Dzieciątkowska, Daniel Stephenson, Marta Suarez Cubero, Sandra Rizzi, Liviu Pirvan, Luca Peruzzotti‐Jametti, Valentina Fossati, , Stefano Pluchino

This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.

Cell stem cell · Oct 21, 2024Peer-reviewedNeuroscience

Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2

Haley A. Vecchiarelli, Kanchan Bisht, Kaushik P. Sharma, Sammy Weiser Novak, Marianela Evelyn Traetta, Monica Emili Garcia‐Segura, Marie‐Kim St‐Pierre, Julie C. Savage, Cory M. Willis, Katherine Picard, Maude Bordeleau, Nathalie Vernoux, Mohammadparsa Khakpour, Rishika Garg, Sophia M. Loewen, , Marie‐Ève Tremblay

This study identifies dark microglia in postnatal mouse hippocampus, showing they perform synapse remodeling via phagocytosis and trogocytosis and depend on TREM2.

bioRxiv · Oct 15, 2024 · PreprintNeuroscience

Integrative single-cell analysis of neural stem/progenitor cells reveals epigenetically dysregulated interferon response in progressive multiple sclerosis

Bong Soo Park, Alexandra M. Nicaise, Dimitrios Tsitsipatis, Liviu Pirvan, Pranathi Prasad, Miguel Larraz Lopez De Novales, Julia Whitten, Luka Čulig, Joseph Llewellyn, Rosana-Bristena Ionescu, Cory M. Willis, Grzegorz Krzak, Jinshui Fan, Supriyo De, Marta Suarez Cubero, , Isabel Beerman

bioRxiv · Feb 9, 2024 · PreprintNeuroscience

Mitochondrial reverse electron transport in myeloid cells perpetuates neuroinflammation

Luca Peruzzotti‐Jametti, C.M. Willis, Regan Hamel, Grzegorz Krzak, Julie A. Reisz, Hiran A. Prag, Vin‐Cent Wu, Y. Xiang, Aletta M.R. van den Bosch, Alexandra M. Nicaise, L. Roth, Georgina R. Bates, H. Huang, Amy E. Vincent, Christian Frezza, , Stefano Pluchino

The paper identifies mitochondrial reverse electron transport in myeloid cells as a driver of neuroinflammation and shows that blocking it protects the CNS in disease models.

bioRxiv · Jan 3, 2024 · PreprintNeuroscience

Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance

Joshua D. Bernstock, Cory M. Willis, Monica Emili Garcia‐Segura, Edoardo Gaude, Daniela Anni, Yan-ja Lee, Luke W. Thomas, Alva M. Casey, Nunzio Vicario, Tommaso Leonardi, Alexandra M. Nicaise, Florian A Gessler, Saef Izzy, Mario Buffelli, Jakob Seidlitz, , Luca Peruzzotti‐Jametti

bioRxiv · Mar 29, 2023 · PreprintNeuroscience

Small Extracellular Vesicles Secreted by Region-specific Astrocytes Ameliorate the Mitochondrial Function in a Cellular Model of Parkinson's Disease

Loredana Leggio, Francesca L’Episcopo, Andrea Magrì, María José Ulloa-Navas, Greta Paternò, Silvia Vivarelli, Carlos A. P. Bastos, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Pierpaolo Risiglione, Fabrizio Pappalardo, Nuno Faria, Luca Peruzzotti‐Jametti, Stefano Pluchino, , Nunzio Iraci

The paper investigates the neuroprotective effects of small extracellular vesicles from region-specific astrocytes in Parkinson's disease, showing they improve mitochondrial function.

bioRxiv · Apr 23, 2021 · PreprintNeuroscience

Time-resolved single-cell RNAseq profiling identifies a novel Fabp5-expressing subpopulation of inflammatory myeloid cells in chronic spinal cord injury

Regan Hamel, Luca Peruzzotti‐Jametti, Katherine Ridley, Veronica Testa, Bryan Yu, David H. Rowitch, John C. Marioni, Stefano Pluchino

bioRxiv · Oct 21, 2020 · PreprintNeuroscience

Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells

Luca Peruzzotti‐Jametti, Joshua D. Bernstock, Giulia Manferrari, Rebecca Rogall, Erika Fernández‐Vizarra, James C. Williamson, Alice Braga, Aletta M.R. van den Bosch, Tommaso Leonardi, Ágnes Kittel, Cristiane Benincá, Nunzio Vicario, Sisareuth Tan, Carlos A. P. Bastos, Iacopo Bicci, , Stefano Pluchino

This study shows neural stem cells transfer functional mitochondria via extracellular vesicles to restore mitochondrial function in target cells, improving disease outcomes in multiple sclerosis.

bioRxiv · Jan 29, 2020 · PreprintNeuroscience