Regulation of the desmosome-intermediate filament linkage enables an adaptive mechano-response within the stratified epidermis
Abbey L. Perl, Rosemary J. DiDominicis, Joshua A. Broussard, Constadina Arvanitis, Kathleen Janee Green
This study identifies the desmosome-intermediate filament network as critical for mechano-response in epidermis, showing its regulation by PP2A-mediated phosphorylation of desmoplakin.
bioRxiv · Aug 31, 2026 · PreprintCell Biology